We invite you to join us at leading scientific and regulatory conferences where our experts will present on studies in toxicology and human health hazard assessments.
Titanium Dioxide (TiO2) and Zinc Oxide (ZnO) in Personal Care Products: Consumer Risks and Regulatory Considerations
Session 7B: Wednesday, September 17
8:00am-8:45am
Study evaluates the human health risks associated with use of Titanium Dioxide (TiO2) and Zinc Oxide (ZnO) in powder sunscreen.
Inside an ISO Class-8 Cleanroom isolation chamber, a brushed-on powder sunscreen containing metal oxide active ingredients (titanium dioxide and zinc oxide) were applied to the face and neck of a human volunteer. Personal breathing zone samples measured respirable-sized particles and speciated metal oxides to quantify exposure concentrations which were input to a human lung dosimetry model (MPPD) to calculate a deposited dose. Deposited doses were compared to health-based criteria (e.g., no-significant risk level) and calculate a margin of safety (MOS) to facilitate a human health risk assessment (HHRA) as part of a product safety assessment.
Particle Deposition in the Human Lung as a Function of Microplastics’ Shape, Size, Orientation, and Type
Microplastics (MPs), breakdown products of environmental physical, chemical, and biological processes, exist in the ambient environment leading to potential inhalation by humans. These microplastics are often fibrous in nature and thus their size, shape, and orientation govern deposition in the human lung. The objective of this research was to determine what combinations of these parameters optimize their deposition in all three regions of the lung, nasopharyngeal, tracheobronchial, and alveolar.
A Review of Quantitative Structure-Permeability Relationship Models Which Predict Dermal Absorption of Chemicals
Quantitative Structure Permeability Relationships (QSPRs) help us understand the quantitative predictions of the movement of molecules across the skin’s biological layers based upon one or more measures of the molecule’s physicochemical and/or structural properties. The objectives of this research were to identify a prioritization scheme for QSPRs constructed from two molecular descriptors, log octanol-water partition coefficient (log kow) and molecular weight (MW) and determine if classification via functional groups and structural similarities enhances existing QSPR models.
Empowering Smarter, Safer Decisions: Chemical Driven Exposure Sciences and Toxicology
RHP Risk Management’s expert scientists combine exposure modeling, laboratory analysis, and toxicology to assess potential risks to human health and the environment. Collaborating with chemical and product manufacturers, consumer good companies, pharmaceutical firms, and legal teams, RHP delivers science-backed insights to improve risk profiles, identify safer alternatives, and support sound, sustainable decision-making.
Understanding Hazard vs Risk in the Media
Context is critical in enabling people to make risk-based decisions that may or may not drive changes in behavior regarding a hazard. Existence of a hazard does not automatically imply the existence of risk.
Chlormequat in Cereal Grains (blog)
The recent articles reporting on the use of chlormequat chloride in commercial agriculture are examples of miscommunication of hazard and risk by presenting an incomplete summary of scientific facts, and failing to contextualize risk in a meaningful way.
Heavy Metals and Glyphosate in Girl Scout Cookies (blog)
In the realm of public health, a clear understanding of the distinction between hazard and risk is essential for informed decision-making. RHP Risk Management examined a recent study reporting on levels of heavy metals and glyphosate in Girl Scout Cookies to provide context to the numbers using established regulatory benchmarks.
