Integrated Epidemiology, Exposure Science & Toxicology – Built for Defensible Decisions
Key Takeaways:
- Risk Management delivers transparent solutions to human health challenges by integrating environmental epidemiology, exposure science, and toxicology, which can inform strategies for compliance with OSHA’s Hazard Communication Standard (29 CFR 1910.1200) and chemical exposure limits.
- Our services, ranging from product stewardship to hazard characterization and exposure modeling, provide support in understanding potential workplace hazards and developing appropriate control measures to meet OSHA requirements for worker safety.
- Utilizing industry-standard and regulatory-accepted methods, RHP’s state-of-the-art Exposure Sciences Laboratory (ESL) helps clients understand potential human health and environmental exposures and risks. The ESL also offers unique opportunities to develop innovative, scientifically sound approaches in exposure science and toxicology for defensible risk assessments.
RHP Risk Management partners with private industry, government, legal, academia, trade associations, and community organizations to address complex human health challenges. Through integrated expertise in Environmental Epidemiology, Exposure Science, and Toxicology, we deliver transparent, reproducible, and legally defensible solutions – ranging from product stewardship to Proposition 65 compliance.
Typical Outcomes
– Regulatory-ready human health risk assessment
– Exposure simulation & measurement in Exposure Sciences Laboratory (consumer & worker)
– Evidence integration: exposure data ↔ toxicology ↔ environmental epidemiology
– Clear, defensible compliance strategy and risk communication
Core Integrated Scientific Approaches: The Three Pillars of Human Health Risk Sciences
RHP evaluates human evidence from cohort, case-control, time-series, and occupational studies, carefully accounting for bias and confounding, and distill consensus-based conclusions on the state-of-the-science for your chemical, product, or scenario. RHP’s epidemiology services include systematic/targeted literature reviews & weight-of-evidence, quality appraisal, bias evaluation, exposure misclassification analysis, and quantitative synthesis & sensitivity analyses.
RHP performs hazard identification and dose-response analysis by integrating animal, mechanistic, and in vitro evidence. Our work includes establishing points of departure, developing benchmark dose (BMD) models, and interpreting modes of action to guide risk estimates and chemical alternatives assessments. We provide support in hazard characterization and mode-of-action analysis, BMD modeling, uncertainty evaluation, potency comparisons, and the development of Occupational Exposure Levels (OELs), Recommended Exposure Limits (RELs), and “safe harbor” style evaluations where appropriate.
Exposure Sciences Laboratory (ESL)
At RHP’s Exposure Sciences Laboratory, we conduct state-of-the-art exposure simulations, analytical testing, and modeling under real-world use conditions. Our team quantifies exposures for both consumer and worker scenarios and synthesizes data to close critical gaps. We provide expertise in consumer product testing, fate and transport migration studies, exposure modeling, as well as occupational and community monitoring and incident response support.
Use Case Process Example: Chemical of Concern (CoC) – Proposition 65 Compliance
For a manufacturer with a chemical listed under California Proposition 65, RHP delivers an end-to-end approach that links exposure data, toxicological interpretation, and epidemiological evidence to inform on Proposition 65 decisions.
- Exposure Sciences Laboratory (ESL)
- Define consumer and worker use scenarios
- Conduct exposure simulation and measurement (inhalation & dermal pathways)
- Model time-weighted exposures; perform exposure reconstruction
- Develop inputs for dose-response and risk calculations (PBPK/BMD)
- Toxicology
- Review animal, mechanistic, and in vitro data relevant to CoC
- Establish points of departure; benchmark dose modeling and uncertainty analysis
- Evaluate cancer hazard classification context and potency for risk characterization
- Environmental Epidemiology
- Review human evidence for chemical exposures in occupational and community settings
- Assess study quality, bias, and confounding; conduct sensitivity analyses
- Integrate findings with toxicology to support a weight-of-evidence conclusion
Compliance Deliverables
- Defensible risk assessment informing whether a Prop 65 warning is required
- Risk management options: product reformulation, labeling strategy, exposure controls
- Documentation suitable for regulatory and legal review
Why RHP for Human Health Risk Sciences
Integrated Evidence: We unify exposure data, toxicology, and epidemiology for a holistic evaluation. When necessary original exposure data is generated in our Exposure Sciences Laboratory for interpretation alongside our toxicological and epidemiological evaluations.
Regulatory-Ready: Study design, traceability, and QA/QC geared for regulatory and legal scrutiny.
Real-World Scenarios: Exposure Sciences Laboratory simulations reflect actual product use conditions for external validity.
RHP’s Human Health Risk Sciences Process
Phase
Scoping
Data Generation
Analysis
Integration
Action
What We Do
Clarify product, use patterns, exposure pathways, and regulatory objectives
Exposure Sciences Laboratory (ESL) exposure testing, field measurements, targeted literature reviews
Exposure modeling, PBPK/BMD, bias assessment, uncertainty analysis
Weight-of-evidence across epi/tox/exposure; risk characterization
Compliance strategy, labeling / reformulation guidance, risk communication
Example Outputs
Scope memo, study plan, protocol
Raw data, lab reports, QA records
Model files, sensitivity runs
Integrated risk assessment
Executive brief, technical appendix
Human Health Risk Sciences FAQs
Q: What is Human Health Risk Sciences?
A: Human Health Risk Sciences at RHP integrates Environmental Epidemiology, Toxicology, and Exposure Sciences Laboratory to deliver defensible risk assessments.
Q: How Does RHP Support Proposition 65 Decision Making?
A: We quantify exposure, interpret toxicological and epidemiological evidence, and integrate findings into a risk determination.
Q: Does RHP test both consumer and occupational scenarios?
A: Yes, RHP conducts lab and field measurement, modeling (including PBPK), and exposure reconstruction.
Q: What deliverables should we expect?
A: Scope and protocol, exposure data, modeling outputs, integrated risk assessment, and a clear compliance plan.
Contact RHP Risk Management
RHP’s experts reduce uncertainty and enable confidence decision-making by delivering reliable, reproducible, and relevant data. Through early and active stakeholder engagement, we design each assessment to align with your specific goals – whether preparing a regulatory submission, supporting litigation, or evaluating a public health intervention.