RHP Risk Management’s Ashish Jachak, PhD, MBA, presented at the 2025 Society of Toxicology (SOT) conference in Orlando, FL. The SOT conference is attended by leading toxicologists, researchers, and industry professionals to explore the latest advancements in toxicology.
Dr. Jachak presented on RHP research:
“Associations Between Particle Shape Factor, Orientation, and Deposition for Microplastics in the Human Lung”
Jachak, A., PhD, MBA; Heckman, B., MPH, CIH; Persky, J., MPH, CIH
Microplastics (MPs), breakdown products of environmental physical, chemical, and biological processes, exist in the ambient environment leading to potential inhalation by humans. These microplastics are often fibrous in nature and thus their size, shape, and orientation govern deposition in the human lung. The objective of this research was to determine what combinations of these parameters optimize their deposition in all three regions of the lung, nasopharyngeal, tracheobronchial, and alveolar.
“A Review of Quantitative Structure-Permeability Relationship Models Which Predict Dermal Absorption of Chemicals”
Jachak, A., PhD, MBA; Heckman, B., MPH, CIH; Pagone, F., PhD, CIH
Quantitative Structure Permeability Relationships (QSPRs) help us understand the quantitative predictions of the movement of molecules across the skin’s biological layers based upon one or more measures of the molecule’s physicochemical and/or structural properties. The objectives of this research were to identify a prioritization scheme for QSPRs constructed from two molecular descriptors, log octanol-water partition coefficient (log kow) and molecular weight (MW) and determine if classification via functional groups and structural similarities enhances existing QSPR models.
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RHP Risk Management is an environmental and occupational health consulting firm of scientists, toxicologists, public health professionals, and risk assessors that cover practices including environmental engineering, industrial hygiene, exposure science, and human health interaction and risk assessment.
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