Key Takeaways:
- RHP scientists analyze the scientific literature of compounds of concern, along with similar compounds for data poor substances, to identify potential human health hazards.
- We supply dose-response analysis and weight-of-evidence frameworks to characterize potential human health risks.
- RHP experts examine the totality of scientific literature, including exposure and epidemiologic data, to assess evidence of causation for specific human health outcomes.
- We perform critical reviews of scientific evidence to support defensible conclusions for risk management, regulatory, and legal decisions.
- RHP translates complex scientific findings into clear, decision-ready insights for clients.
Defensible Toxicological Science to Evaluate Hazards, Characterize Potential Risk, and Support Regulatory and Legal Decision-Making
Toxicology is central to understanding whether chemical exposures can cause adverse health effects and at what levels risk may occur. RHP’s toxicologists apply rigorous scientific methods to evaluate toxicological evidence, characterize dose-response relationships, and interpret hazard data in the context of real-world exposures.
Our team integrates toxicology with exposure science, epidemiology, and risk assessment to develop scientifically defensible conclusions that inform regulatory compliance, product safety and stewardship, and litigation strategy. From emerging chemicals to legacy substances, RHP supports clients in interpreting complex toxicological data and translating scientific findings into clear, decision-ready conclusions.
RHP’s Toxicology Services
Hazard Identification and Evaluation
Critical review and synthesis of toxicological literature, mechanistic studies, and regulatory assessments to identify potential health hazards associated with chemical exposures.
Dose-Response Analysis
Evaluation of toxicological endpoints to establish points of departure and characterize dose-response relationships used in health risk assessments. Our expertise includes:
- Mechanistic and Mode-of-Action Analysis: Assessment of biological mechanisms and weight-of-evidence frameworks to evaluate whether observed effects are biologically plausible in humans.
- Benchmark Dose and Toxicological Modeling: Application of benchmark dose modeling and other quantitative approaches, including new approach methodologies (NAMs), to derive health-based thresholds used in regulatory and risk assessment contexts.
- Support for Risk Characterization, Risk Management, Regulatory, and Legal Decisions: Preparation of toxicological evaluations, hazard summaries, expert reports, and technical analyses supporting regulatory submissions, product safety and stewardship decisions, and litigation.
What RHP Delivers
- Evaluation of toxicological evidence for emerging chemicals and legacy substances (e.g., PFAS, microplastics, and other substances of concern).
- Hazard identification and human health risk assessment.
- Benchmark dose modeling and point-of-departure determination.
- Interpretation of animal toxicology and mechanistic studies.
- Integration of toxicological evidence with exposure and epidemiologic data.
- Preparation of expert reports and regulatory technical documents.
Contact RHP experts to reduce uncertainty and enable confidence in decision-making by delivering reliable, reproducible, and relevant data. Through early and active stakeholder engagement, we provide customized solutions that support clients with their specific goals.